Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP) In stage one of a two-stage genome-wide association study (GWAS). Genome-wide significant association with survival at chromosome 12 was found. LRRK2 has been associated with sporadic and familial forms of Parkinson's disease. The mechanism of this association might be through a lncRNA-regulated effect on L
