Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction

Cardiac hypertrophy is a compensatory response to pressure overload leading to heart failure. We identified the pivotal roles of the mammalian homolog...

Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease

Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer's disease (AD) The kidney is thought to be responsible fo...

Association of serum neurofilament light chain levels with clinicopathology of chronic inflammatory demyelinating polyneuropathy, including NF155 reactive patients

Serum neurofilament light chains (NfLs) serve as a biomarker of axonal damage in patients with chronic inflammatory demyelinating polyneuropathy. Seru...

Distinct microRNA profiles for complete hydatidiform moles at risk of malignant progression

MicroRNAs are small non-coding RNAs with important regulatory functions. Little is known about the role of microRNAs in premalignant disease. The stud...

Radiation Therapy Oncology Group consensus panel guidelines for the delineation of the clinical target volume in the postoperative treatment of pancreatic head cancer

The postoperative abdomen has been a difficult area for effective radiotherapy. These new guidelines will help physicians create fields that better en...

Relationship Between Quality of Life of Children With Cancer and Caregiving Competence of Main Family Caregivers

The study was to describe the caregiver's proxy report of the quality of life of children with cancer. Caregiver's competence, marital status, and ti...

“The back-up vasectomy reversal.” Simultaneous sperm retrieval and vasectomy reversal in the couple with advanced maternal age: a cost-effectiveness analysis

Researchers looked at the cost-effectiveness of different fertility options in couples with a female of advanced maternal age. They found the most cos...

Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts

Ca2+ leak in atrial myocytes plays an essential role in the development of atrial fibrillation (AF) Leak is induced by mechanical stretch due to eleva...

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