Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes

High expression variants of C4, a gene of the innate immune complement system, were shown to confer susceptibility to schizophrenia. How elevated C4 e...

Cortical diffusion kurtosis imaging and thalamic volume are associated with cognitive and walking performance in relapsing–remitting multiple sclerosis

In MS, pronounced neurodegeneration manifests itself as cerebral gray matter (GM) atrophy. The study looked at the relationship between morphological...

Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer

Patients younger than 40 years usually present with early-stage endometrial cancer with a favorable prognosis. This study aimed to evaluate the progno...

Tofacitinib as monotherapy following methotrexate withdrawal in patients with psoriatic arthritis previously treated with open-label tofacitinib plus methotrexate: a randomised, placebo-controlled substudy of OPAL Balance

Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis, rheumatoid arthritis, and ulcerative colitis. Flares of worsen...

Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer

The panel convenes to examine relationship between margin width and ipsilateral breast tumor recurrence. Positive margins are associated with a 2-fold...

The Association between Mortality and Male Infertility: Systematic Review and Meta-analysis

Six studies from 2006 to 2020 examined male infertility and mortality. Compared to fertile men, infertile men had a higher risk of death. The risk of...

Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern

Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation. Abnormal gap junction (GJ) coupling and fibrosis are i...

The role of polymorphisms rs2070744 and rs1799983 eNOS gene in patients with POAG: a systematic review and meta-analysis

Glaucoma is a progressive disease of the optic nerve that has several underlying causes. The eNOS gene polymorphisms may increase the risk of POAG amo...

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