Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study

Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promis...

Comparison of breast cancer and cervical cancer stage distributions in ten newly independent states of the former Soviet Union: a population-based study

More than 50% of breast cancer cases across the region were at stages I–II. The proportion of stage I cases was highest in the screening age group of...

Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial

This is an open-label, randomized, controlled, phase 3 trial done at 29 hospitals in China. Patients had pathologically confirmed HER2-positive metast...

Global costs, health benefits, and economic benefits of scaling up treatment and imaging modalities for survival of 11 cancers: a simulation-based analysis

Treatment, imaging, and quality of care could avert 12% of cancer deaths globally, ranging from 2% in high-income countries to 38% in low-income natio...

High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial

This open-label, randomised, phase 2 trial was done at 22 public hospitals in Norway, Denmark, and Sweden. At 2 years, 66% of patients in the 60 Gy gr...

The impact of the COVID-19 pandemic on radiotherapy services in England, UK: a population-based study

In 2020, mean weekly radiotherapy courses fell by 19% in April, 6% in May, and 11% in June compared with corresponding months in 2019. The largest red...

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders. Most common is sporadic Creutzfeldt-Jakob disease (sCJD) Variants...

Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study

Since 2015, the arthropod-borne viruses (arboviruses) have spread across the Americas causing outbreaks. These outbreaks have been accompanied by incr...

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