Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial

We aimed to assess the safety and efficacy of galcanezumab, an antibody to calcitonin gene-related peptide. The primary endpoint was the overall mean...

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains access to the CNS. We investigated the brain tissue of patien...

Monogenic variants in dystonia: an exome-wide sequencing study

Dystonia is a clinically and genetically heterogeneous condition that occurs in isolation or in combination with other movement disorders. We sequence...

Long-term follow-up from the ORATORIO trial of ocrelizumab for primary progressive multiple sclerosis: a post-hoc analysis from the ongoing open-label extension of the randomised, placebo-controlled, phase 3 trial

Time to onset of disability progression was confirmed with four measures and time to requiring a wheelchair was also analyzed. At the study end, the p...

Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial

Biotin (MD1003) might enhance neuronal and oligodendrocyte energetics, resulting in improved cell function, repair, or survival. MS-SPI randomised, do...

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial

Methylphenidate, modafinil, and amantadine are commonly prescribed medications for alleviating fatigue in multiple sclerosis. Authors: The study did n...

Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study

The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of surviva...

Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis

There has been no systematic analysis of a stenosis-risk association in cohort studies. The 5-year ipsilateral stroke risk increased with the degree o...

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