Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

Isocitrate dehydrogenase 1 (IDH1) mutations occur in approximately 13% of patients with intrahepatic cholangiocarcinoma. 185 patients were randomly as...

Cytoreductive surgery and HIPEC for malignant ascites from colorectal cancer - a randomized study

The efficacy of different timings of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in controlling malignant ascit...

Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism

Pharmacological ascorbate (P-AscH-, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Studies in pancreatic...

Randomised clinical trial: palliative long-term abdominal drains vs large-volume paracentesis in refractory ascites due to cirrhosis

Palliative care remains suboptimal in end-stage liver disease. Study assessed palliative long-term abdominal drains in liver disease to determine recr...

Randomised clinical trial: standard of care versus early-transjugular intrahepatic porto-systemic shunt (TIPSS) in patients with cirrhosis and oesophageal variceal bleeding

Early-transjugular intrahepatic porto-systemic shunt (TIPSS) recommended in international guidelines for high-risk patients with oesophageal variceal...

A prospective, randomized trial of thrombin versus cyanoacrylate injection in the control of acute gastric variceal hemorrhage

Acute gastric variceal hemorrhage (AGVH) is a serious complication of portal hypertension. Glue injection is standard therapy for acute hemostasis, bu...

Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis

A total of 32 studies assessing 3952 patients were included in this meta-analysis. SSM was quite useful for ruling out the presence of HREV thereby av...

Systematic review with meta-analysis: liver manifestations and outcomes in COVID-19

Elevated liver chemistries and pre-existing chronic liver disease (CLD) have been reported in COVID-19. The presence of CLD does not alter the outcome...

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