Impact of COVID-19 on women and children and the need for a gendered approach in vaccine development

Women and children are widely considered the most vulnerable in times of emergency, whether in war or during a pandemic. The inclusion of pregnant and lactating mothers in clinical trials for the development of vaccines is of vital importance, say the researchers. They suggest a gendered approach to ensure the specific needs of women and their newborns are considered.

Comparing COVID-19 vaccine allocation strategies in India: A mathematical modelling study

Researchers used an expanded SEIR model with social contact matrices to assess age-specific vaccine allocation strategies in India. Prioritizing COVID-19 vaccine allocation for older populations led to the greatest relative reduction in deaths. Findings support global recommendations to prioritize -19 vaccines for older age groups. Optimal vaccine allocation strategies will depend on vaccine characteristics, the strength of non-pharmaceutical interventions.

Efficacy and safety of COVID-19 vaccines in older people

Older people and care home residents are likely to be amongst the first to be vaccinated, but these patient groups are usually excluded from clinical trials. Their safety and efficacy in older people is critical to their success. Although the speed and impact of the pandemic on older people with frailty justify an approach where they are offered vaccination first, patients and their carers and supervising health care professionals alike will need to make a decision on accepting vaccination base

COVID-19 - Recent advancements in identifying novel vaccine candidates and current status of upcoming SARS-CoV-2 vaccines

The COVID-19 pandemic caused by SARS-CoV-2 has spread rapidly. Studies on the roles of asymptomatic and mildly infected subjects in disease transmission, use of antiviral drugs, and vaccination of the general population will be very important for mitigating the effects of the eventual return of this pandemic.There also is a need to comprehensively compile the details of previous studies on SARS-related vaccines that can be extrapolated to identify potent vaccine targets for developing COVID-19 v

Unilateral axillary Adenopathy in the setting of COVID-19 vaccine

Radiologists should consider recent COVID-19 vaccination history as a possible differential diagnosis for patients with unilateral axillary adenopathy. Hyperplastic axillary nodes can be seen on sonography after any vaccination but are more common after a vaccine that evokes a strong immune response.

DNA vaccines against COVID-19: Perspectives and challenges

The coronavirus disease 2019 (COVID-19) is caused by a novel coronovirus known as SARS-CoV-2. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. DNA vaccination is a promising alternative to conventional vaccines.

The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding

Push enteroscopy (PE) is at present considered to be the most effective diagnostic procedure. In the present trial in patients with CGB, wireless CE had the highest diagnostic yield and was significantly superior to PE. Both CE and PE were safe and were not associated with any morbidity.

Endoscopic management of refractory gastroesophageal reflux disease

The study evaluated the safety and efficacy of endoscopic band ligation in the management of gastroesophageal reflux disease. 150 patients with refractory GERD were assigned to an EBL group and a control group.