Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials
Melanocortin 4 receptor (MC4R) receptor plays a part in body weight regulation. Severe early-onset obesity can be caused by biallelic variants in genes that affect the MC4R pathway. Eight participants in. the POMC trial achieved at least 10% weight loss in approximately 1 year.
