Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial

Lansoprazole was either given twice daily for 16 weeks or matched to placebo. Primary outcome was symptomatic response at 16 weeks measured using the...

Systematic Review and Meta-Analysis of Prophylactic Transarterial Embolization for High-Risk Bleeding Peptic Ulcer Disease

The present systematic review determined the role of transarterial embolization (TAE) as a prophylactic treatment in bleeding peptic ulcers. Patients...

Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score

Bleeding after endoscopic submucosal dissection (ESD) is a frequent adverse event after early gastric cancer surgery. We aimed to develop and external...

Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis

There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of Barrett's oesophagus. Prevalence of BO among...

Impact of disconnected pancreatic duct on recurrence of fluid collections and new-onset diabetes: do we finally have an answer?

Disconnected pancreatic duct (DPD) is a frequent occurrence in cases with walled-off necrosis (WON) The impact of DPD on recurrence of collection afte...

Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. We aimed to identif...

Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis

Alcoholic hepatitis (AH) is a common but life-threatening disease with limited treatment options. Neutrophils in contact with bile ducts were quantifi...

Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson's Disease

Focused ultrasound subthalamotomy in one hemisphere improved motor features of Parkinson's disease in selected patients. Adverse events included speec...

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