Diagnostic yield of endoscopic ultrasound-guided tissue acquisition in autoimmune pancreatitis: a systematic review and meta-analysis

There is limited evidence on the diagnostic performance of endoscopic ultrasound (EUS)-guided tissue acquisition in autoimmune pancreatitis (AIP) 15 studies with 631 patients were included, of which four were prospective series and one randomized trial. Overall diagnostic accuracy of EUS tissue acquisition was 54.7% (95% confidence interval, 40.9%-68.4%) with a clear superiority of FNB over FNA. FNB provided level 1 of histological diagnosis in 44.2% of cases (30.8%-57.5%) as compared to 21.9% w

Comparison of Three Methods of Gallbladder Drainage for Patients with Acute Cholecystitis Who Are at High Surgical Risk: A Network Meta-Analysis and Systematic Review

Percutaneous gallbladder drainage is used for the treatment of patients with acute cholecystitis who are at high surgical risk. It is unclear which procedure is associated with the best outcomes. EUSGBD appears to be preferable with respect to both safety and efficacy, say authors. The study looked at 13 studies that compared at least two of the drainage procedures.

Combined chemotherapy and EUS-guided intra-tumoral 32-P implantation for locally advanced pancreatic ductal adenocarcinoma: a pilot study

This study evaluated clinical outcomes of combined chemotherapy and Endoscopic Ultrasound (EUS) guided intra-tumoral radioactive phosphorus-32 (32P OncoSil) implantation in locally advanced pancreatic adenocarcinoma (LAPC). ​Technical success was 100% and no procedural complications were reported.EUS guided 32P OncoSil implantation is feasible and well tolerated and was associated with a 42% rate of surgical resection in our cohort.

Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) technique and analgesic efficacy in patients with pancreatic cancer: A systematic review and meta-analysis

Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN) can be used to treat abdominal pain in pancreatic cancer. It can be administered in three different ways, depending on the site of needle insertion: central injection, bilateral injection and celiac ganglia neurolysis. There was no evidence of a difference in response rates between the three techniques. Serious complications have been reported for BI and CGN but not for CI.

EUS-guided pelvic drainage: A systematic review and meta-analysis

EUS-guided pelvic abscess drainage is a procedure that uses an echoendoscope to visualize an area of interest for needle insertion and placement of a stent, catheter, or both for drainage of the target abscess. Eight studies with a total of 135 patients combined were included in our analysis. The rate of technical success was 100% and the pooled rate of clinical success was 92% (95% confidence interval [CI]: 87%, 98%; P = 0.31; I2 = 15%) The calculated pooled rates of adverse events was 9.4% wit

Favorable effect of endoscopic reassessment of clinically staged T2 esophageal adenocarcinoma: a multicenter, prospective cohort study

Clinical tumor stage of esophageal adenocarcinoma is determined by endoscopic ultrasound and/or CT-scan. accuracy of these tools is low for stages T1 and T2, which may result in overtreatment. We aimed to assess the proportion of cT2 EAC downstaged to cT1 after endoscopic reassessment.ERA downstages about half of the cT2 tumors to cT1 suitable for ER. ERA has a substantial clinical impact on therapeutic management preventing overtreatment in 40% of patients.

Transpancreatic biliary sphincterotomy versus double guidewire in difficult biliary cannulation: a randomized controlled trial

Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) increases the risk of post-ERCP pancreatitis (PEP) The study compared two advanced rescue methods, transpancreatic biliary sphincterotomy (TPBS) and a double-guidewire (DGW) technique in difficult common bile duct (CBD) cannulation. No difference existed in PEP severity between the groups.

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of UK deaths. Short telomere length is associated with IPF and chronic obstructive pulmonary disease (COPD) There was no evidence to infer that telomeres caused COPD, however. Telomere shortening might be a contributory factor in IPF, suggesting divergent mechanisms in COPD. Investigation of therapies that improve telomere length is warranted.